In cases where slowing of the hearttends to be dangerous in itself, more especially in poisoning withmuscarine, pilocarpine and their allies, atropine is indicated. The nerve endings in the penis release chemical messengers, called neurotransmitters, that signal buy meridia craigslist the corpora cavernosa (the two spongy rods where to purchase phentermine 37.5mg in the uk online of tissue that span the length of the penis) to relax and fill with blood. The same objection applies to the allegedastringent effect of iron in nephritis. In animals bloodyurine is sometimes passed after colchicine.in poisoning with colchicine the leucocytes are at first reduced inthe peripheral circulation, but afterwards increase to beyond thenormal number.all of these symptoms are exactly those caused buy meridia craigslist by a large numberof poisons, including some of the bacterial toxins and the heavymetals. Pde-5 inhibitors work depends on the person taking it and buy meridia craigslist how much he takes. Phentermine 15 mg capsule side effects r-warfarin)tadalafil (10mg and 20 buy cheap carisoprodol online europe mg) buy meridia craigslist had no clinically significant buy meridia craigslist effect on exposure (auc) to s-warfarin orr-warfarin (cyp2c9 substrate), nor did tadalafil affect changes in prothrombin time induced bywarfarin.aspirintadalafil (10mg and 20 mg) did not potentiate the increase in bleeding time caused by buy meridia craigslist acetyl salicylicacid.antidiabetic medicinal productsspecific interaction studies with antidiabetic medicinal productswere not conducted.pregnancythere are limited data from the use of tadalafil in pregnant women. With the exception of nitrous oxide, all inhaled anes-thetics in current use cause a dose-dependent decrease in tidalvolume and an increase in respiratory rate (rapid shallow breath-ing pattern). It is relatedchemically to choline. It isprobable that the increase in bronchial secretions is due to thefirst stage of nausea, rather than to direct action.the quebracho alkaloids, aspidospermine, aspidospermatine, aspidosamine, quebrachine, etc., produce practically thesame symptoms as apomorphine. Motion of the interface,such as comes about during shaking of a solution, appears toaccelerate the surface-associated denaturation. Where to buy valium 5mg tablets the detailed knowledge of thebinding spot in buy meridia craigslist the target also allows for the design of a totally new molecularstructure that optimally interacts with the target. Carbenicillin sodium, car-benicillin free acid, ticarcillin sodium, and ticarcillin free acid. If there is local hemorrhageit may be stopped by this powerful, local, contractile effect on thevessels.other nerve endings in smooth muscles than those in buy meridia craigslist blood also called epinephrin and suprarenin. Later, the entirecentral nervous system is paralyzed producing unconsciousness,collapse and death due mainly to paralysis of the respiratorycentre in the meduua. Tadalafil can increase the potential for orthostatic signs and symptoms, including increase in heart rate, decrease in standing blood pressure, dizziness, and headache. If the minimum occurs at about ph 7,the two ions are of equal effect. When the cal-culated f values are smaller than the buy meridia craigslist critical f values, the datamay be combined, and the pooled data analyzed.a printout for the combined lots as well as for each individuallot provides the estimated rate of degradation and its standarderror in percentage per month for each ingredient. These symptoms may be produced in animals also.another early xanax online pharmacy reviews symptom is anaemia, which may be due in part tomalnutrition, but is attributed mainly to an abnormal destruction ofthe red cells of the blood; the white corpuscles are increased in manycases but buy meridia craigslist not in all. Examples of private nonforprofitorganisations are the buy meridia craigslist european organisation for the research and treatmentof cancer (eortc, www. In clinical trials with tadalafil 5mg taken once a day forthe treatment of benign prostatic hyperplasia, dizziness and diarrhoea were reported more frequentlyin patients over buy meridia craigslist 75 years of age.single doses of up to 500 mg have been given to healthy subjects, and multiple daily doses up to100 mg have been given to patients. There weremarginal increases buy meridia craigslist in uncommon tumors in male rats at a dose of 15 mg/kg (slightly greater thanthe maximum human dose) but not at 30 mg/kg.furosemide was devoid of mutagenic activity in various strains ofsalmonella typhimuriumwhentested in the presence or absence of anin vitrometabolic activation system, and questionablypositive for gene mutation in mouse lymphoma cellsin the presence of rat liver s9 at the highestdose tested. Alprostadil may also be administered into the urethral opening of the penis. Empty the cheapest generic alprazolam 1.5mg online in uk stomach by inducing vomiting or by gastric lavage. Provides information on the biological activities of small molecules. In pneumonia more especially,great improvement is often seen after digitalis. Finally, the preservative purchase meridia mastercard must not impact the safety or comfort of the patientwhen administered. Sabatine ms, cannon cp, gibson cm, et al, for the clarity-timi 28 investigators. Theadvantage of a phenotypic approach is that drug molecules can be selected onthe basis of their effect on the outcome of a disease process as a whole withoutbeing limited to one single target. Its action uponthe heart or pupils is the same as that of coniine.sparteine produces almost the same effect on the centralnervous system as coniine, but is much weaker than the latter.it diminishes the force of contraction of the heart and paralyzesthe vagus. Pde6, which is involved in phototransduction in the retina. It is ativan fast shipping therefore possiblethat alkali may delay the evacuation of the stomach when given withsolid food, but may have less effect when taken with abundant water.the arrival of acid in the duodenum normally causes constrictionof the pyloric orifice, and this may perhaps be lessened w t hen alkaliesare given, particularly in cases buy meridia craigslist of hyperacidity; but the action ofalkali on this reflex is still undetermined.in the small intestine the alkalies have been shown to have an in-direct effect, through their diminishing the acidity of the gastricjuice. Perhaps this action in relax-ing spasmodic contractions may also explain the beneficial effectsobtained in cases of incontinence of urine in children, in which bella-donna has long been the most reliable remedy.to lessen pain. Was due to the discovery of its efficacy in ague or malaria, and withgrowing experience in the disease and its treatment, buy meridia craigslist the confidence inthe drug, or rather in its chief alkaloid, has constantly increased, untilthe action of quinine in malaria is now quoted as the best example ofa specific in therapeutics. The slow onset and prolonged durationof action of lorazepam limit its usefulness for preoperative medica-tion or induction of anesthesia, especially when rapid and sus-tained awakening at the end of surgery is desirable. The saponins have a peculiar affinity for lecithin whichthey buy valium in hanoi dissolve, while cholesterin forms an insoluble chemical compoundwith many of them.in addition to the plants which owe their action to the presenceof these bodies, a number of drugs contain saponins along with othermore important principles. In this regard, study subjectswhose blood pressure was well controlled, the reduction was minimal and similar to that seen inhealthy subjects. Complete buy meridia craigslist impotence was reported by 5&x00025; buy meridia craigslist of men at 40 years of age and 15&x00025; at 70 years of age; however, a higher prevalence of complete impotence was seen in men with concomitant buy meridia craigslist illnesses. Other regulatory documents used during drug development are the investigative medicinal product dossier (impd), the investigators brochure (ib) and the request for aspecial protocol assessment to start carcinogenicity studies in experimentalanimals. While deen has cut out buy meridia craigslist glass after glass of sweet tea and taken up treadmill walking off camera, she plans few changes on the air. The guideline also introduces the concept of a bridging study that anew region may require in order to determine where to buy alprazolam 1.5mg online with american express whether clinical data from aforeign region are acceptable for its own population (only if the results aredemonstrated to be similar in both regions).two different development strategies can be applied to study (and copewith) these regional or population differences. — average (u.065 « br. Bettman statesthat in subacute poisoning in rabbits, the red cells and haemoglobinare diminished, and nucleated red cells appear in the blood in somenumber; and from this it has been suggested that arsenic may acceleratethe destruction of the blood cells and thus induce a more buy meridia craigslist rapid formationindirectly as a sort of compensation; buy meridia craigslist but there is no evidence that thera-peutic doses increase the destruction of the blood cells and this viewmay be dismissed as fanciful. Inthe frog antipyrine causes an increase in the reflex irritability, which some-times leads to tetanic convulsions and is followed by depression, loss of thevoluntary movements, and eventually by complete paralysis and death. (5 11r4 5).resina or rosin, residue after the distillation of tiupentine. Studies on the induction by furosemide of chromosomal aberrations in micewere buy generic ativan 1mg in florida inconclusive. The mean per-subject proportion of successful sexual intercourse attempts was 68% for patients comparedto 52% for patients on placebo.benign prostatic hyperplasiawas studied in 4 clinical studies of 12 weeks duration enrolling over 1500 patients with signsand symptoms of benign prostatic hyperplasia. Vigra - specially for men perfect for impotence, premature ejaculation and effective to enlarge penis. It is intensely buy meridia craigslist bitter so that its taste may be detected in thedilution of 1 to buy meridia craigslist 700,000.ooio. Cns effectsetomidate is a potent cerebral vasoconstrictor, as reflected bydecreases in cerebral blood flow and icp.
The defectin slow acetylators (of isoniazid and similar amines) appears to becaused by the synthesis of less of the nat2 enzyme rather than ofan abnormal form of it. The typical stabil-ity related tests for metered-dose aerosols include appearance,assay, impurities, plume geometry, emitted dose, particle sizedistribution of the emitted dose, and number of doses per unit.in addition, stability studies on leachables may be required.shelf life of buy meridia craigslist metered-dose aerosols drug products may also bedependent on the orientation that the drug product is stored.typically most meridia bars online reviews canister type products are tested at least in theupright orientation.dry-powdered inhalation productsa dry-powdered inhalation product consists of drug with excipi-ents delivered in a dry powdered form. You are using an outdated browser. 68, after treatment withthyroid extract for 5 months, height 30 inches, circumference of abdomen 15 inches.(osier.)these cases. Some of these are nor-mally put in action by nerve impulses, which they transmit buy meridia craigslist to thecontractile or secretory cells, and their paralysis by atropine leads tothe failure of part of the nervous control of the organ (many glands,pupil, bronchial muscle, oesophagus, and heart). The multitudinous impulses generated in the auricles descendirregularly to the ventricle, which responds with a rapid beat varyingnot only in rhythm but also in strength ; many of the contractions aretoo weak to expel any blood into the aorta, while others cause largepulses, and these are intermixed in the most confused fashion; thepulse is thus extremely irregular (fig. Some spirillar infections in animals are said to reactto mercury in the same way as syphilis, however.mercury was recommended by hamilton in the beginning of the lastcentury in the buy meridia craigslist treatment of acute febrile affections, and the greatestabuse unquestionably prevailed in the earlier decades. Men who get back pain and muscle aches usually get it 12 to 24 hours after taking. Enhancement of fantasy-induced sexual arousal in men through training in sexual imagery. It remains contracted 12-14 hours,and according to some observers a difference in the size of the twopupils may be made out for several days. 45piscidia erythrena was at one buy meridia craigslist time much in vogue in theunited states as a sleep producer and to check cough, but it wasrecently discovered that its active principle had no narcotic effectand in large doses acted much like physostigmine.summary of buy meridia craigslist the "group buy meridia craigslist action buy meridia craigslist —depression of thesense buy meridia craigslist of pain before complete narcotic auction occurs. Similar toother intravenous induction agents, midazolams effect on sys-temic blood pressure is exaggerated in hypovolemic patients. Thus fatty degeneration of many organs is induced by its prolongeduse, the nitrogen of the urine is found to be increased buy meridia craigslist and the glycogen dis-appears from the liver. Beacon press integrates the latest thinking in psychology and psychiatry to provide a comprehensive and readable overview of psychological topics how old do you have to be to take xanax of particular concern to women. These effects on the metabolite are not expected to be of clinicalconsequence.15effects of tablet on other drugsin vitrostudies:sildenafil is a weak inhibitor of the cytochrome p450 isoforms 1a2, 2c9,2c19, 2d6, 2e1 and 3a4 (ic50 >150μm). But it must be employed in small qunatities, as large doses, such as have frequently been advised,tend to depress the central nervous system and thus to aid rather thanto antagonize the action of morphine on the respiration. You have to get a prescription for this hair treatment but it's worth seeing buy meridia craigslist a doctor about. Whether or not it has beencorrelated with biological effectiveness, the standard dissolu-tion test is a simple and inexpensive indicator where to buy tramadol 100mg online with mastercard of a product’sphysical consistency. For bph, consideration should be given to other urological conditions that may cause similar symptoms. In man, usually very little of the haemoglobinis thus transformed, and ambien 10mg buy even after large quantities have been inhaledno abnormal coloration of the blood is noticeable, but it has beendemonstrated buy meridia craigslist recently that the alteration of the haemoglobin is thecause of death in some animals, through the blood becoming incapableof carrying oxygen to the tissues. Fn&x2019;s permanent forum for sager vedrorende oprindelige folk, blev det bekr?ftet at fn afholder verdenskonference om buy meridia craigslist oprindelige folk i 2014. If this buy meridia craigslist is the case, then the man will experience thinning at the temples followed by more loss on the top of the head. The destruction of the red blood corpuscleswhich occiurs produces the anaemia.the nitrogenous metabolism as may be judged by thenitrogen in the urine is increased by small doses but is decreasedby large ones. Learn about your health condition and how it may be treated. The size ofthe pupil is regulated by two sets of nerves, the motor oculi and thesympathetic, and the ciliary fibres of both of these are interrupted byganglia in their passage from the brain to the iris, those of the motoroculi by the ciliary ganglion, those of the sympathetic by the superiorcervical ganglion the varying effects of nicotinemay be due to its stimulating the one ganglion more strongly in onespecies of animals, the other in another. Maca affects the endocrine system buy meridia craigslist via the pituitary gland in both men and women. As soon as marketing authorisation is received the manufacturer of the drug will start discussions with the health authorities about priceand reimbursement. In this scenario, telomere shortening ultimately results in telomere dysfunction, fusion and genomic instability, creating the large-scale rearrangements that are characteristic of these tumours. buy meridia craigslist however,halothane, enflurane, and sevoflurane have little effect on heartrate, probably because they attenuate baroreceptor input into buy meridia craigslist theautonomic nervous system. In dilute solution, they are sometimesapplied to the skin to lessen excessive local sweating and diluted vinegar isoften used to sponge fever patients.in cases of corrosive poisoning with acids, the first indication is toneutralize the acids as far as possible by giving alkalies. Furthermore, because thedecline in the placebo group was more rapid, the difference between treatment groups also continued toincrease throughout the studies, resulting in a 277-hair difference buy meridia from usa (p<0.001, propecia [n=219] vsplacebo [n=15]) at 5 years (see figure below).patients who switched buy meridia craigslist from placebo to propecia (n=425) had a decrease in hair count at the end ofthe initial 12-month placebo period, followed by an increase buy meridia craigslist in hair count after 1 year of treatment withpropecia. During animal safety testing, dosing studiesare conducted, and the highest no-effect dose is determined.in xanax recovery addition to dose, plasma concentrations of the drug are fol-lowed, and noted toxicities are correlated to dose and/or plas-ma concentration.generally, buy sibutramine bars 2mg online once discovery testing shows therapeutic promise,the chemical synthesis, formulation development, and animalsafety testing occur concurrently.y be wasted on earlier buy meridia craigslist failures, successful candidateswill be ready for human testing more quickly. Theseinclude the st george's respiratory alprazolam tafil questionnaire (sgrq), aself-completed questionnaire devised to measure hrqol inindividuals with chronic airflow limitation [15, 16]. In the frog the symptoms where to buy diazepam in hanoiwhere to purchase meridia online no prescription are those of central nervous paralysis,and later of heart failure. Thereis evidence that treatment withphenytoin leads to decrease intestinal absorption of lasix, and purchase tramadol online in canada consequently to lower peakserum furosemide concentrations.methotrexate and other drugs that, like lasix, undergo significant renal tubular secretion mayreduce the effect of lasix. A candidate drug that has transferred from early development to late development is referredto in this book as adrug under development.when the final results of drug development show that the drug under development is safe and effective and can be manufactured at a high level of quality,all the data are collected, integrated and submitted to the health authorities inorder to obtain authorisation for marketing. The hospital environmentwith intensive and widespread use of broad-spectrumantibacterials is particularly likely to promote theselection of resistant diagnosis buy meridia craigslist of bacterial infection confirmed– clinical symptoms/signsplus– positive microbiologytreat with most appropriate antibioticaccording to predominant causativeorganism(s) and sensitivities (includinglocal sensitivity patterns)consider– alternative (or additional) diagnosis– poor penetrance of antibiotic to site of infection– possible change in antibiotic therapyis bacterial sensitivity profile available?treat with appropriate antibioticis purchase generic soma in australia bacterial infection likely?no antibiotictreatmentconsider other measures (e. buy meridia craigslist examplesof platform technology to product conversion are the following:(1) ligand pharmaceuticals, founded by dr. Even small quantities, such as are used thera-peutically, cause stimulation of certain parts of the central nervoussystem, for the stimulation of the inhibitory cardiac centre in themedulla often slows the heart both in therapeutics and in experimentson mammals.the central nervous system, then, undergoes distinct stimulationunder digitalis.
Smith has found that the inhalation of oxygen undersome pressure causes irritation, congestion and consolidation of the lungs inmice and birds.oxygen is inhaled through a mask connected with a large container whichis filled from a tank of the compressed gas. These dossiers are used at critical time points during the development of a new drug. The anaesthesiawith buy meridia craigslist ether or chloroform is usually preceded, if not by morphineand scopolamine, by the use of some much buy meridia craigslist more rapidly actingvolatile anaesthetic, as nitrous oxide, ethyl chloride, etc. Itis reviewed by the expert reviewers in the national member states regulatoryauthorities and ethics committees. They can shut down the pituitary gland and throw the body's hormonal system out of balance. This means that the development of a newdrug is not only time consuming and expensive soma pill but also requires strong management and leadership in order to reach development milestones on time,to control budgets, to evaluate investments and to manage human resources.in general, this process is led by buy meridia craigslist a portfolio team that manages the drug portfolio of a company, while project teams manage the process of discovery anddevelopment. Withsmall doses in man, profile sweating often accompanied by salivation are practically the only s3naiptoms observed. Qt interval was evaluated at buy meridia craigslist the time of peak tadalafil concentration in a randomized, want to buy clonazepam 1mg in the uk double-blinded, placebo, and active (intravenous ibutilide) -controlled crossover study in 90 healthy males aged 18 to 53 years. Glomerular filtration rate should receive 500 mg or 250 mg every 24 hours, depending onseverity of the infection.hemodialysis patients should receive 500 mg or250 mg every 24 hours, depending on severityof the infection. Mayo foundation for medical education and research (mfmer). Not take this medicine more often than once daily as needed. It possesses some action onthe heart, the. Frequently, the particles of a floc are in physical contact. In the blood and tissues they do not exist as acids butas buy meridia craigslist salts, for the reaction of the blood must remain slightly alkalineacids 551throughout life, and if sufficient acid be given to neutralize the alkaliesof the body, the animal dies before the blood becomes neutral, buy meridia craigslist althoughafter death it" may be found to be acid. This technology refersto the generation of compounds in sets, or libraries, that aretypically chemically related and made by combining sets of re-actions, such that the chemical steps are efficiently conducted.combinatorial chemistry was initially applied to amino acidsand nucleotides by affymax and nexagen, respectively. Stai utilizzando un browser obsoleto! The tincture of strophanthusis rather stronger than the tincture of digitalis and has a smaller dose.the tincture of squills of both pharmacopoeias should be given in twicethe pharmacopoeial dose to elicit the same effects as the tincture ofdigitalis. In health, quinine has no effect on the temperature as ageneral weight loss pills like speed rule; in some cases a very slight fall, in others an equally in-significant rise in the thermometer follows its administration.this antipyretic action of quinine has been the subject of a buy cheap sibutramine 15mg numberof investigations, sibutramine prescription ny which buy meridia craigslist have given varying results. Micro-scopic examination or an x-ray diffraction measurement buy meridia craigslist maybe used to monitor these parameters.in some instances it is necessary to use an ointment base thatis less than ideal, to achieve the required stability. In order to elicit this action, the drug must be injectedintravenously. Well, i began cycling again and working out, joined a gym. It does not seem to have a marked depressanteffect upon the heart, yet nmnerous accidents have occurredduring its use clinically.mixtures of anesthetics buy meridia craigslist have been used for manyyears, mainly on the principle that they might be more activeand safer than the single anaesthetics. Robert found that repeatinjection of small quantities of the citrate of iron induces congestion of thekidney and the appearance of casts and albumin in the urine.iron, like the other heavy metals, would therefore seem to have a sperifcirritant effect on the intestinal and gastric mucous membrane, and to a la?extent on the kidney. If, on the other hand, more heat isdissipated than usual through exposure to cold, buy meridia craigslist the combustion of thetissues is increased and more heat is formed. The clinical significance of this finding is unclear, but it may be of benefit to patients.azithromycin does not interact significantly with the hepatic cytochrome p450 system. The dose is gradually increased to one that buy meridia craigslist improvessymptoms (and survival) with careful monitoring of bloodpressure. It is conducted to provethat the target is responsible for or is involved in the buy meridia craigslist development of the disease. Enzymes that are capable of dissolving a recently formedblood clot, such where to buy alprazolam 1mg online as streptokinase, tissue plasminogen activator(tpa), and urokinase, have been approved and are useful underspecific primary care circumstances in buy meridia craigslist the treatment of stroke.major advances have been made in the field of gastrointestinalphysiology; many new gastrointestinal polypeptide hormoneshave been isolated and characterized, and their primary func-tions have been determined. Thiscontraction extends throughout the intestlnar tract, so ativan for back pain "that repeatedevac uation of thn b owel wmr somewhat larger quantities may leadto a tetanic contraction of the whole intestine with almost completeobliteration of the jumen. (for example, 5 glasses of wine or 5 shots of whiskey). Radiopharmaceuticals is a leader in the development of molecular imaging products with the potential for earlier and more effective detection, buy meridia craigslist diagnosis and monitoring of major chronic human diseases. The latter may even occur after verysmall doses buy meridia craigslist of some of these substances.according to the action of the members of this group theyare indicated in therapeutics for three different purposes, firstly,as antipjnretics, i., want to buy ambien with american express to lower febrile temperature; secondly, asanalgesics to decrease pain; thirdly, as antiseptics. The same metal attached to different acids may therefore inducevery different effects, in the one buy meridia craigslist case acting chiefly as buy meridia craigslist an astringent,in the other as an irritant and corrosive.tw f4iflrqpfap nf tvip «tfll whivh i s carried down in the precipitatealso influences the local effect; thus mercury is intensely poisonous anddestroys buy meridia craigslist the cells in which it is deposited, while lead is a less powerfulpoison and the cells may recover even if lead buy meridia craigslist has been deposited onthem.in addition, s alts which have a very strong affinity for water with-draw fluid frotn the cells, and thus act more strongly on them thanothers which have not this character; for example dried alum is muchmore destructive to the tissues with which it comes in contact thanalum containing its ordinary water of crystallization.the different metallic salts therefore vary in their local action withinwide limits — from the formation of mildly astringent membranes tothe production of widespread necrosis and destruction of order diazepam 10mg online with prescription tissue.the most powerful corrosive salts of any metal are those which aremost rapidly dissociated into ions, that is, the chl orides and nitrates ,provided they are soluble. Dose, 2 pills u., 515 grs.mistura ferri composita (u.), griffith's mixture, is formedby mixing ferrous sulphate, potassium carbonate, and various flavoring substances. Many of the currently used buy meridia craigslist anti-spasmodics, anticonvulsants, local anesthetics, nonnarcoticanalgesics, chemotherapeutic agents, and buy meridia craigslist hypnotics have beenproducts of this approach.another research approach is to identify, isolate, and purifycompounds from biologically active mixtures. If one be fed on milk only, anotheron milk to which iron is added, the liver of the latter is found to containmore iron than that of the control. It is also employed, but less than in thepast, in febrile diseases, as pneumonia and typhoid fever. Treatment should be symptomatic and no specific antidote is available.11 withdrawal period(s)chicken (meat diazepam visa & offal) 1 dayduck (meat & offal) 9 daysturkey (meat & offal) it owes its activity to the inhibition of the development of the peptidoglycan network structure in the bacterial cell wall.amoxicillin is a semisynthetic penicillin with a broad spectrum of activity against gram positive and gram negative bacteria.2 pharmacokinetic particularsamoxicillin is well absorbed following oral administration and it is stable in buy meridia europe the presence of gastric acids. Intwo of these studies decreases were observed in sperm count and concentration related to tadalafiltreatment of unlikely clinical relevance. A great deal of weight was formerly laidon the use of purgatives and buy 2mg xanax online uk emetics as preliminaries to the treat-ment of malaria with quinine, and the former are undoubtedly ofservice sometimes, although it is unnecessary to delay the quininetreatment by waiting for the intestines to be buy meridia craigslist evacuated.quinine is used not only as a remedy, but also as a prophylacticagainst malaria. Once the dossier is complete and checkedfor quality and consistency it is submitted by the regulatory department of thedrug development organisation to all relevant regulatory authorities.