SuperCeramics

Worth Way, Keighley, West Yorkshire BD21 5AE

}

Opening Hours

Mon - Sat: 8.00 - 17.00
Saturday: 8.30 - 17.00
Sunday: 10.30 - 15.00

Telephone

01535 600777

SuperCeramics Tile Warehouse

Worth Way, Keighley, West Yorkshire BD21 5AE

}

Mon - Sat: 8.00 - 17.00

Saturday: 8.30 - 17.00
Sunday: 10.30 - 15.00

Telephone

01535 600777


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Information, you are able to find updated and useful information described in a very brief and easy to understand manner. Auc and a want to buy ultram 50mg with paypal 3-fold increase in cmax when co-administered with 5 mg in healthy want to buy ultram 50mg with paypal volunteers. Forph sensitive compounds, any of these interactions may alterthe ph and cause precipitation.vitamins, essential oils, and almost all fats and oils can beoxidized. It is sometimes mixed with flour or driaigypsum and water to a paste (canquoin's paste), when a less want to buy ultram 50mg with paypal active causticis desired. Digitoxin has been prescribedin doses of rs mg. The gcp guideline states that the sponsor shouldensure that the trials are adequately monitored, leaving it to the sponsor to determine the appropriate extent and nature of monitoring but in reality alltoo often the monitoring activity covers the full data set. This accelerated want to buy ultram 50mg with paypal beat is the characteristic featureof the adrenaline action, but it want to buy ultram 50mg with paypal often gives place to the slow, full beatcharacteristic of want to buy ultram 50mg with paypal inhibitory activity. The appetite is bad, and the patient complains of heaviness,discomfort or pain in the region of the stomach, general weakness and exhaus-tion. The correlation between intracavernosal pressure and cavernosal blood oxygenation. 0-2. The process of gender role socialization prescribes appropriate male and female behavior regarding sexuality. Depressant tocentral nervous system and heart.— the main use of where to buy soma 350mg in london quinineis as a specific in want to buy ultram 50mg with paypal the treatment of malarial fever. Under normal circumstances it is unusual for apharmacy to accept want to buy ultram 50mg with paypal any product with less than 6 month datingremaining on a want to buy ultram 50mg with paypal product.much has been written about the development of a stablepharmaceutical product. (tadalafil), dubbed "le weekend drug" in europe, is a new treatment for erectile dysfunction (ed) from lilly icos llc. Erectile dysfunction (ed) is a common male sexual dysfunction and affects the individual's physical and psychological well-being. Screening impotence by home noctural tumescence self-monitoring. When thetvalue is significant, theprintout contains an estimate of the shelf life with the appropri-ate confidence interval. The papillary muscles undergothe same changes as the rest of the ventricular wall, contracting morestrongly and more completely than before the want to buy ultram 50mg with paypal administration of thedrug.as occasionally happens, the amount expelled is increased because theventricles contract more completely. In want to buy ultram 50mg with paypal addition, precipitated silver chloride particles show their cubic nature under the electron microscope. Just as with some other oxidizable substances, the power ofan organism for burning alcohol may be increased by habit, so thathabitual drinkers can take much larger quantities with less actionthan those not accustomed to its use.as might be expected, on account of its combustion in the body,alcohol can replace carbohydrate and fats in the diet in isodynamicamoimts; so seven grammes of alcohol are practically equivalentto four and onetenth grammes of carbohydrate or nine want to buy ultram 50mg with paypal and threetenths grammes of fat. This "lead line" is due to the precipitation of lead sulphaby the hydrogen sulphide arising from septic processes in want to buy ultram 50mg with paypal the teeth andgums; it is often absent if the teeth and mouth are kept clean whealthy, and its presence does not indicate lead poisoning, but onlycontact want to buy ultram 50mg with paypal with lead. The excess acetylcholine,in turn, stimulates cholinoceptors to evoke increased responses.these buy ultram 100mg in australia drugs act primarily where acetylcholine is physiologicallyreleased and are thus amplifiers of endogenous acetylcholine.some cholinesterase inhibitors also inhibit butyrylcholinesterase(pseudocholinesterase). Higher level cheap tramadol 200mg online with paypal of quality has an incremental cost and top quality ultram 100mg online pharmacy overnight with zeroerror is very expensive. According tosome observers, the terminations of the autonomic nerves are rendered moreexcitable under oxalates, and this manifests itself in salivation, ready dilationof the pupil, variations in the rate of the heart, and in an abnormal sensitivenessto adrenaline and pilocarpine (chiari and frohlich).when the ordinary nerve-muscle preparation is soaked in oxalate or fluoridesolution, the same twitching and tremor of the muscle is observed as when thesalt is injected into the frog. Understanding want to buy ultram 50mg with paypal the concepts of bioavailability and bioequiva-lence testing is essential in the drug development process be-cause they create the foundation for regulatory decision makingwhen evaluating formulation changes and lot-to-lot consistencyin innovator products. The administration of iodine where to purchase ultram 50mg online legally cheap leads to anincrease in the iodine want to buy ultram 50mg with paypal of the thyroid gland.small quantities of iodine may be given internally to want to buy ultram 50mg with paypal many personswithout eliciting any symptoms except buy generic tramadol 50mg online legally from canada those which are clearly due tothe local action. I would suggest you attend to this part of your process as the extra cost is unnecessary. In clinical pharmacology studies, tadalafil was shown to potentiate the want to buy ultram 50mg with paypal hypotensive effect of nitrates. The synthesis of methyltellurium is one of the few known esin which a compound with methyl is formed in the animal body, and is of gretfbiological importance. They act much more slowlyand for a longer time than nitroglycerin.another series of bodies which may be mentioned as occasionally actinglike nitrites, although more feebly, are the nitro-bodies. This hydrophilic shell forms a steric barrier that prevents close contact between particles and inhibits coagulation (“steric stabilization”).nonionic surfactants also reduce the sensitivity of hydrophobicdispersions toward ultram brand name coagulation by salts (i., they increase thecoagulation values). They are absorbed as salts of the alkalies, but do not as ageneral rule reduce the available alkali of the blood or render the urine moreacid, because they are buy generic tramadol with american express oxidized to carbonates in the tissues. Stai utilizzando un browser obsoleto! Thusthe notorious aqua tofana of the sixteenth and seventeenth centuries,owed its activity to the presence of arsenic, and various arsenical com-pounds have been used up to the last few years more largely thanalmost any other poison in suicide and homicide. Even when the alkaliadministered has been neutralized by the gastric juice, the body isrendered more alkaline, because a certain amount of a the carbonate ofthe blood and buy tramadol online without a prescription tissues is spared, which would normally have been usedto neutralize the hydrochloric acid ultram 50mg prescription san diego before it could be reabsorbed. Under the best circumstances, sexuality and impotence are sensitive subjects. Co-administration of probenecid with immediate-release ciprofloxacin results in about a 50% reduction in the ciprofloxacin renal clearance and a 50% increase in its concentration in the systemic circulation. It is notonly the collaboration between want to buy ultram 50mg with paypal the drug development organisation and itscontributing partners and service providers that drives the development ofa new drug, health authorities also play an important want to buy ultram 50mg with paypal role in guiding drugdevelopment organisations during their development efforts.because of the multidisciplinary nature of a drug development projectit is impossible for a single individual to be knowledgeable about all thecontributing scientific disciplines in drug development that range fromchemical engineering to clinical practice. Diet and environmental factors contribute to individual variations indrug metabolism. It also resemblescurara in paralyzing the sympathetic ganglia, but want to buy ultram 50mg with paypal this paralysis seems to bepreceded by a short stage of stimulation; the ganglia are affected by quantitiesof coniine which are insufficient to cause paralysis of the nerves to voluntarymuscle, but its action on these ganglia is not so powerful as that of nicotine,and the details of this action may therefore be left for discussion under thelatter drug.the heart is affected through the stimulation want to buy ultram 50mg with paypal and subsequent paralysis ofthe ganglia on the inhibitory fibres, which leads first to slowing and later tosome acceleration of the pulse. Though it is commonly referred to as the knoxville formula apparently for the city of its original introduction, a number of slightly varying formulas have been in use around the country. Hemodialysis (performed between 24 and 30 hours post-dose) contributed negligibly to tadalafil or metabolite elimination. Repeated doses, however, sometimes cause symp-toms resembling those observed after iodides (iodism), although thesehave been much less often induced by iodine, which is comparativelyseldom administered internally. On the other hand, the fever is want to buy ultram 50mg with paypal not reduced sorapidly and generally not to the same extent as by the latter, and thelarge quantities of quinine required are liable to cause discomfortfrom their effects on the brain and hearing. The phosphates excreted are increased in the sameratio as the nitrogen, and the increase is obviously due to the samecause, augmented protein waste.in some cases sugar has been found in the urine after thyroid treat-ment, and in a considerable percentage of persons it seems to cause atendency to glycosuria, as is shown by the appearance of sugar in theurine after the ingestion of large quantities of sugar, which wouldnormally be oxidized in the tissues. Because animal reproduction studies are not alwayspredictive of human response, this drug should beused during pregnancy only if clearly needed.labor and delivery:oral ampicillin-class antibiotics are poorly absorbed during labor. Recently, we proposed a new paradigm for understanding the role of the aging and the tumor microenvironment in cancer onset. Take each dose of Acyclovir with a full glass or water. Examined with the spectroscope, methamoglobin is very often found in it, while in other cases an absorption line isobserved between tramadol 200mg prescription guidelines the yellow and the red, which does not seem to correspondto that of any of the ordinary haemoglobin products, and has therefore beencalled the nitrobenzol-haemoglobin line. Greenville news, success, demand studios and american city business journals.

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Ed include vacuum pump therapy, injection therapy involving injecting a substance into the penis to enhance blood flow, and a penile implantation device. Another conditionwhich presents still greater difficulties in diagnosis is alcoholic neuritis.but in the latter skin eruptions are extremely rare, coryza is not present,and there are generally more order pain meds online legally marked brain symptoms than in arsenicalcases. Only a few c.of a strong serum are necessary, and these do not contain enough of theforeign components to cause these want to buy ultram 50mg with paypal symptoms. Indiscriminate use leads topatient resistance which is very dangerous as has where to purchase ativan 2mg online with paypal been the case with tuberculosis drugs. 10) can be reduced to a few best possiblecandidates for transfer to late lead optimisation. This pigmentation (argyria) was much commoner formerly,when the nitrate was used in the treatment of epilepsy. Letter, the excitability of theventricle may be so great that it adopts its want to buy ultram 50mg with paypal own regular rhythm (fig. Thus, the rate of degradation may have to be studied overan undesirably long period of time in order to determine theproduct’s stability under normal storage conditions.to avoid this undesirable delay in evaluating possible formulations, the manufacturer attempts to predict stability underconditions of room temperature or actual storage conditions byusing data for the rate of decomposition obtained at several elevated temperatures. want to buy ultram 50mg with paypal when ether is allowed to evaporate upon the skin, it produces cold and local anaesthesia.ether does not want to buy ultram 50mg with paypal affect the contractile power of the parturientuterus in moderate anaesthesia, but in deeper stages, when want to buy ultram 50mg with paypal verygroup of ether and chloral. There followed a curve of decadence which probably reached its lowest period shortly afterthe fall of the buy generic tramadol 100mg in china roman empire. True tolerance is attainedvery imperfectly by animals from the use of buy tramadol nevada repeated small doses, butwhen larger amounts are used some tolerance is soon acquired (edmunds) .animals which have acquired tolerance for nicotine also resist the actionof lobeline. Key chain tag has a glossy finish and comes with a hole for hardware. Quite recently a new process has beenintroduced by which the oil is extracted by steam, without being exposedto the air, and it is stated that oil thus obtained is less disagreeablethan any other.the codliver oils used in therapeutics differ considerably in appearance and want to buy ultram 50mg with paypal in composition, the older preparations being brownish incolor and having a strong fishy odor and a somewhat acrid, disagreeable taste, while the oil prepared by the more recent processes is paleyellow in color, and has much less odor and a bland taste.codliver oil, like the oils derived from the livers of other animals,contains the ordinary glycerin oleate, palmitate and stearate, and alsoglycerin esters of some unidentified nonsaturated acids, along withlecithin. want to buy ultram 50mg with paypal importance of the medial amygdala in rat penile erection evoked by remote stimuli from estrous females. Lead hasalso been advised in cases of haemorrhage from the lungs, kidneys anduterus, but is quite valueless here, tramadol 50mg prescription pills as it acts as a styptic only whenapplied locally. Spinal block reveals roles for brain and spinal cord in the mediation of reflexive penile erections in rats. – Remembering the name of the Batchelder Award. Digitoxin seems to contractat least temporarily the vessels of the umbs and want to buy ultram 50mg with paypal of the splanchnicarea. Buy propecia here part below and choose one of the trusted online pharmacies which offer propecia at low price. Tremors and even convulsions may also occur. On theother hand, moulds grow abundantly in a solution of potassium arsenite (1 percent.) containing some organic matter, and the alcoholic fermentation proceedsin the presence of arsenic, although it is somewhat retarded at first; verydilute solutions of arsenic even accelerate the fermentation, as is true of mostother antiseptics. 36, a). In the vertebratesthis is obscured by the fact that most of the iron is contained in thehaemoglobin of the blood, and its importance in the other tissues isgenerally ignored. Banking scorcard is a capacious impartial annual audit of responsible for safety and effectiveness. The heart andrespiration are fi rst accelerate d and then slowed , from a direct actionon the heart and on the respiratory centre. Whenapplied to the eye, it dilates the pupil almost want to buy ultram 50mg with paypal as rapidly as atropine,but less completely, and the action passes off much sooner. Butwhen strophanthin, digitalin, or convallamarin is used, a buy veterinary tramadol further complicationarises, for these have a somewhat less marked vascular action, and though thevessels of the abdominal organs are contracted in the same way as by digi-toxin, those of the extremities dilate. This difference in exposure does not warrant a dose adjustment.non-clinical data reveal no special hazard for humans based on conventional studies of safetypharmacology, repeated want to buy ultram 50mg with paypal dose toxicity, genotoxicity, carcinogenic potential, and toxicity toreproduction.there was no evidence of teratogenicity, want to buy ultram 50mg with paypal embryotoxicity or foetotoxicity in rats or mice that receivedup to 1000 mg/kg/day tadalafil. — iron has long been used in the want to buy ultram 50mg with paypal treatment of anaemia, more especially of the form known as chlorosis, and itwas tacitly assumed that it was readily absorbed from the order ultram 100mg with american express alimentarytract and was utilized by the tissues to form haemoglobin. Tramadol 100mg prescription no insurance it acts through the inhibition of biosynthesis of where to purchase ultram 50mg in japan cellwall mucopeptide. Colic and diarrhoea are frequentlyobserved, or diarrhoea and constipation may alternate. The mean per-subject proportion of successful sexual intercourse attempts was 71.9%with 5 mg compared to 48.3% with placebo.the maintenance of the effect was evaluated in an open-label extension to one of want to buy ultram 50mg with paypal the studies, whichshowed that the improvementin total international prostate symptom score seen at 12 weeks wasmaintained for up to 1 additional year of treatment with 5mg.paediatric populationa single study has been performed in paediatric patients with duchenne muscular dystrophy (dmd)in which no evidence of efficacy was seen. 2 end of phase 2therapeutic exploratory trials (phase 2) are important clinical trials as theyexplore different dosing regimens from which one with the best want to buy ultram 50mg with paypal efficacy andsafety will be selected for the conduct of therapeutic confirmatory clinical trials in a large and more diverse population want to buy ultram 50mg with paypal of patients (phase 3). Category b — (tadalafil) is not indicated for want to buy ultram 50mg with paypal use in women. In this case, the blood levels of the uncoatedtablet were depressed markedly, while the film-coated and en-teric-coated tablets showed relatively little difference in bloodlevels.from this second study, it want to buy ultram 50mg with paypal might be concluded that film coat-ing appears to impart the same degree of acid stability as anenteric coating. Therefore, ich has issued a guide-line on ethnic factors in the acceptability of foreign clinical data [34], latercomplemented by a questions and answers document to clarify key issues[35] , while the ema released a reflection paper on the extrapolation ofresults from clinical studies conducted outside the eu to the eu-population[36] . In aqueous solutions free drug molecules are in equilibriumwith drug molecules bound in a where to buy ultram in hanoi complex and, thus, the releaseof drug molecules from cyclodextrin-containing vehicle will depend on the drug/cyclodextrin molar ratio and the want to buy ultram 50mg with paypal km:n value(eq. Drug-drug interactions antacids ciprofloxacin has been shown to be active against most isolates of the following bacteria, both in vitro and in clinical infections ciprofloxacin [see indications]. Actually started out in studies as a medication to want to buy ultram 50mg with paypal reduce blood pressure. Geriatric patients in general, dose selection and dose adjustment for the elderly patientshould be cautious, usually starting atthe low end of the dosing range propecia®(finasteride), a synthetic 4-azasteroid compound, is a specific inhibitor of steroid typeii5α-reductase, an intracellular enzyme thatconverts the androgen testosterone into5α-dihydrotestosterone (dht). Quinoline(ch 7 n) was soon found to be dangerous from its producing collapse, but itsderivatives kairine (c,h,(oh)n— c 2 h 6 ), kairoline (ch s (ch 3 )(oh)nh) andthalline (c 9 h 9 (och a )nh) want to buy ultram 50mg with paypal were used extensively, although they have nowbeen entirely abandoned; analgen is a quinoline derivative, still prescribed toa very limited extent.a new antipyretic was introduced in 1884 under the name of antipyrine,which is derived from phenylhydrazine, and has proved superior to all of theearlier drugs. These symptoms are quickly followed by those ofparalysis and there occurs decreased respiration, increase inpulse rate and fall of want to buy ultram 50mg with paypal blood pressure.

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Other studies, especiallythose reported by nelson, levy, and others, confirmed, beyonddoubt, the significant effect of the dissolution behavior of drugson their pharmacological activities. It is therefore not alwayseasy to determine how far the improvement is to be attributed to thedigitalis and how far to such auxiliaries as rest and general treatment.such measurable symptoms are often presented as dropsy, however,and the fall in weight from diuresis under digitalis is as significantevidence as the fall in pulse rate in fibrillation. Lighting, temperature, humidity and ventilation must be such that product quality is not affectedduring production and storage and that the operation of machinery is notimpaired. Consumers should want to buy ultram 50mg with paypal understand that does not protect against sexually transmitted disease and safe sex practices are encouraged. In animals, classical experiments upon cocks' combs and pigs' ears want to buy ultram 50mg with paypal invariably demonstrate this action. Thank you, ARISE, for providing a means for my church to celebrate God’s love and to hear a pastor that want to buy ultram 50mg with paypal the kids can listen buy cheap xanax 2mg in thailand to face to face … sermons just for them. Ringing or roaringsounds in the ears, accompanied by slight deafness, are produced bymoderate quantities and large doses are not infrequently followed bycomplete loss of hearing for a time. Santesson found that antipyrinetended to increase the power of the frog's muscles, and several observershave noted that the nerves and motor terminations are paralyzed by thedirect application of this drug. Pylorihas been shown to reduce the risk of duodenal ulcer recurrence. Atropine, then, seems to select the terminations of thesecretory fibres of the chorda tympani for paralysis and to leave allothers unaffected. Such, bitter aikaiitids as strvciimiie andouinine, which have a powerfd consuijiional acticxu are excluded. Dose, 2 mg.(a gr.oleatum veratrince (u.), 2 per cent. Some escapes by the salivary glands, however, and smallquantities are excreted by the stomach as hydriodic want to buy ultram 50mg with paypal acid and some-times as free iodine; iodide has also been found in want to buy ultram 50mg with paypal the tears, perspira-tion, milk, sebum, and in the secretion of the nasal mucous membranes.more iodide is found in the blood than in any of the fixed tissues; theiodides 521skin is also rich in iodide, while the lungs, kidneys and lymph glandscontain smaller quantities; the brain and fatty tissues have merelytraces; diseased organs are said to take up more than sound ones.iodides are much more rapidly excreted than bromides, for 65-80 percent, of the iodide appears in the urine within 24 hours after its ad-ministration, and no iodide reaction is obtained from any of the secre-tions a week after the treatment has ceased. It is absorbed rapidly and cir-culates in ultram 50mg prescription amounts the want to buy ultram 50mg with paypal blood longer than the arsenites, which are taken up by the tissuesrapidly and thus can exert only a transient action on parasites living in theplasma. Central oxytocinergic and dopaminergic mechanisms regulating penile erection in conscious rats. The majorcirculating metabolite is the methylcatechol glucuronide. Chloral has want to buy ultram 50mg with paypal also been found valuable in lessening the pains oflabor and in affording sleep during the middle of prolonged parturition. When the antivenin want to buy ultram 50mg with paypal is available,however, its injection should certainly form part of the treatment ofsnake bite.many other immune sera have been proposed, but as yet none ofthem have been generally accepted as of value.toxins want to buy ultram 50mg with paypal are also found in a number of the higher plants.ricin is ultram 50mg prescription laws an intensely poisonous albumin found in the seeds purchase generic tramadol 50mg online in uk of cheapest generic ultram 200mg in korea ricinus com-munis along with castor oil, order tramadol online reviews which does not itself contain this principle, however.ricin is poisonous in doses of about nfoo milligram want to buy ultram 50mg with paypal per kilogram body weightinjected subcutaneously, but seldom causes any symptoms when swallowed,as it is apparently destroyed for the most part by the digestive ferments. If you haven’t already then set up a profile on LinkedIn to get yourself started. This isbetrayed in many cases by the can you buy tramadol otc in cabo development tramadol 200mg online pharmacy canada of ear symptoms aftercomparatively small doses, but in others symptoms arise which do notappear in the great majority of people even after large doses. For small companies that have invested all their resources ina single drug, a refusal for want to buy ultram 50mg with paypal market authorisation may result in the death ofthe company. Frequently, the want to buy ultram 50mg with paypal particles of a floc are in physical contact. — thyroid extract is not a dangerous remedy,unless in cheap tramadol in canada certain cases. Sbp 85 mmhg and one patient had a decrease in sbp of 30 mmhg. Antimony is certainly as closely related to arsenic as tothis group, and may be regarded as a connecting want to buy ultram 50mg with paypal link between them.the metals as such do not induce any symptoms except from theirmechanical properties. Implications for the differentiation between organic and psychogenic impotence. In the tissues, however, they are oxidized and form carlxniates, sothat the effects are those of the chloride before absorption, and those of thecarbonate subsequently. It increases the secretion of the bronchialmucous membrane, and further tends to render it more fluid, so thatthe mucus can be coughed up more easily. When you get the prescription from your doctor make sure he understands you are on high blood pressure medication. The inhibition of pde5 in these tissues by sildenafil may be the basis for theenhanced platelet antiaggregatory activity of nitric oxide observedin vitro, an inhibition ofplatelet thrombus formationin vivoand peripheral arterial-venous dilatationin vivo.pharmacokinetics want to buy ultram 50mg with paypal and metabolismtablet is rapidly absorbed after oral administration, with a mean absolute bioavailability of41% (range 25-63%). The bicar-bonate of potash is more frequently used for this purpose than theothers, and the carbonic acid liberated in the stomack may be ofimportance in the action. The power of muscular movementsoon disappears completely, first from the muscles of the limbs,and lastly from those of respiration. 8,000 Sq. Different mutations,inherited as autosomal recessive traits, account for the enzymedeficiency. As a result, the basket-stirred-flask test (usp apparatus 1) was adopted as an officialdissolution test in 6 monographs of theunited states pharma-copeia(usp) andnational formulary(nf), in 1970. 1one of the results of quinine medication in want to buy ultram 50mg with paypal early cases of malariais the reduction of the enlarged spleen, and this has led to its use inother diseases of the spleen with enlargement. A few experiments have been carried out, but byno means enough to establish the truth of the statement satisfactorily,and the chief argument brought forward in its support is that codliveroil forms an emulsion in the testtube more rapidly than other oils. Ed's complete disregard want to buy ultram 50mg with paypal of the laws of nature in the cul-de-sac, in which he seems to be the want to buy ultram 50mg with paypal one in charge in some instances. The secretion of the pancreas is normally augmented on thepassage of an acid fluid through the pylorus, and if the acidity ofthis fluid be reduced by the administration of alkalies, a much smallerquantity of pancreatic juice is thrown into the intestine. The lack want to buy ultram 50mg with paypal buy drug ultram 100mg with visa of proper labeling or safety information is common, with noprescription online pharmacies (npops)purchased medications and provides consumers with little to want to buy ultram 50mg with paypal no information, on dosage scheduling, dosage administration,or potential side effects (orizio, merla and gelatti 2011). They must be usedimmediately after solution and the solution should be made with freshly dis-tilled water. As examples showing therapydirected against the specific cause of disease, we have the use ofquinine in malaria, mercury and salvarsan in syphilis, diphtheriaantitoxine in diphtheria, vermicides for intestinal parasites, etc.