In combinations with cocktails of other drugs, hiv pro-tease inhibitors are the main avenue of therapeutic approachfor controlling hiv today. Alcohol is probably the greatest single cause of secondary impotence. Thus in framboesia (yaws),recurrent fever, and vincent's angina, it is remarkably efficient, and inspirillosis of the order sibutramine online in the uk lower animals an equal success has followed its use.in malaria salvarsan is order sibutramine online in the uk inferior to quinine, and in sleeping sickness itappears to be less useful than atoxyl. It normally undergoesglucuronidation and sulfation to the order sibutramine online in the uk corresponding conjugates,which together make up 95% of the total excreted order sibutramine online in the uk metabolites.the alternative p450-dependent gsh conjugation pathway accounts for the remaining 5%. This order sibutramine online in the uk effect is less marked forisoflurane, sevoflurane, and desflurane. Now a nimaber of firms standardize their tinctures and fluidextracts. The agency also recognizedthat providing a single list based on common criteria would bepreferable to evaluating drug products on the basis of differingdefinitions and criteria in various state laws. Its action is more easily localized than that ofpotash and on the other hand is more powerful than the metallic salts, suchas silver nitrate and ambien 40 mg zinc chloride. Contact your doctor or health care provider right away if any of these apply to you. For example, the anticancer drug cisplatin has a coordination numberof 4 (fig. Integrated analysis of order sibutramine online in the uk clinical adverse experiencesshowed that during treatment with propecia, 36(3.8%) of 945 men had reported one or more of theseadverse experiences as compared to 20 (2.1%) of934 men treated with placebo order sibutramine online in the uk (p=0.04). Perhaps it's his hygiene, perhaps it's not, we don't know. Phenylhydrazine itself is avery poisonous substance producing a brown coloration of theblood due to methaemoglobin formation and also to a coloredproduct of this drug. Propecia tablets are coated and this avoids contact with the active ingredient during normal handling. Hypophysectomy prevents acth-induced yawning and penile erection in rats. Plastic containers have become very popular for storing phar-maceutical products. I have two second-pace trophies from CBC Trivia in 2007 and 2009. Increasing power of oxidation by constant ingestion. Every step of the process is carefully timed andlinked to the previous step and the next step. Not infrequently these renal changes s. Many publications demand careful prospective con-trolled clinical trials, but the ethics and practicalities of suchstudies often make their demands unrealistic. This treatment works to destroy much of the herpes virus, diminishing it's the growth and the potential to spread. In the usa, approximately10-12% of the health care dollar is presently spent on prescriptiondrugs. The reason for this evidently is that in order to par-1 a curious contrast is presented in this respect by gymnemic acid, which is obtainedfrom the gymnema silvestre, and which removes the sensation of sweetness, while ' bitter"is less affected and "acid" and "salt" are recognized as readily as usual. Generally,the evaluation criteria for case-controlled where can i buy phentermine cheap and cohort studiesaddress proper sample-frame definition, compatibility of casesand controls, drug-exposure validations, unintended-effect as-certainment procedures, and related considerations. Similarly, genetic polymorphisms ( gstm1 ) ingst (mul isoform) expression can lead to significant adverseeffects and toxicities of drugs dependent on its gsh conjugationfor elimination. Most complexes with coordination number6 are octahedral, that is, the bonds lie along the x, y, and zaxes of a coordinate system with the metal ion at the origin.example of such a complex are the cis and trans isomers ofdichlorotetraamminecobalt(iii) chloride (figure 18-2).metal ions that are found within cells form coordination complexes with small molecules such as porphyrins that are themselves bound to proteins. — 4.016.)8.the tincture and fluidextract contain a phentermine uk larger percentage of digitoxinthan the infusion because the latter is more easily extracted by alcohol.strophanthus (u.), seeds of order sibutramine online in the uk strophanthus hispidus and strophanthus semina (b.), seeds of strophanthus kombe, containing the nonglucosidal bitter principle, strophanthin.tinctura strophanthi(u.6c. Zovirax is active during any forms of herpes virus: one of the mostcharacteristic features is the rapidity with order sibutramine online in the uk which the disease changefrom one type to another, order sibutramine online in the uk and the diversity of the symptoms presentat one time. The anaesthetic actionis, however, merely an instance of its general toxicity, for if broughtcocaine 357in contact buy diazepam washington with other forms of living matter in the concentration usedin anaesthetising nerve ends, it is purchase valium 5mg in china poisonous to all the structures whichhave been examined. If a large number of drops are formed, cheapest generic ultram 200mg no prescription further reduction in area can occur by having the drops coalesce, as when afoam collapses or when the liquid phases making up an emulsion separate.in the centigrade-gram-second (cgs) system, surface tensionis expressed in units of dynes per centimeter (dyne/cm), whilesurface free energy is expressed in erg/cm2. Difficilecolitis.precautionsgeneral:the possibility of superinfections with mycoticor bacterial pathogens should be kept inmind during therapy. Tyramine or hydroxyphenylethylamine, and ergamine or histamine (0-iminazolylethylamine,jy-j order sibutramine online in the uk r yc.ch2.nh2) along with several less important basessuch as isoamylamine and acetylcholine are also present in ergot. Long-time use of steroids can permanently damage the testicles. Eczema, bullae,pemphigus and purpura arise less frequently from the use of iodides.in some cases a more or less defined area of oedema has been observedin the face.the secretion of urine is generally increased by the administrationof iodides, as of other salts of the alkalies, though they seem to haveno specific action on the kidneys. Paroxysms of the most acute agony arefollowed by intervals of comparative freedom from pain, but in theseintervals some tenderness of the abdomen cheapest generic tramadol in canada may be complained of,while during the attack pressure generally relieves the pain. The inhibitory termina-tions in the heart are paralyzed; but the therapeutic dose in manis too small to elicit cheapest generic ativan 2mg in japan this effect, and the pulse is therefore unaltered inrate or may be slower, owing to the hypnotic action. Do not increase or decrease the amount of grapefruit order sibutramine online in the uk products in your diet without first talking to your doctor. This can help your caregiver find the right treatment for you. The people who want to use these tablets for long time order sibutramine online in the uk should order sibutramine online in the uk use the lower doses because it is necessary for you to maintain the internal body functions and systems. Ifparticulate levels are order sibutramine online in the uk found to be excessive, steps must order sibutramine online in the uk be takento bring them within acceptable limits so as not order sibutramine online in the uk to compromisethe quality of the product. The licensing out of pharmaceutical activities implies a written contract between the œcontract giver and the œcontractacceptor in which the responsibilities of each party are order sibutramine online in the uk clearly defined andindicate the conditions under which the responsible pharmacist will releasethe drug product.complaints and recallsall complaints and other information on drug products that might beindicative of a quality problem must be evaluated in accordance with writtenprocedures. (i 5.) 2.aqua chloroformi (u.) contains yi per cent, chloroform.dose: buy adipex-p brindley injected into his penis was a non-specific vasodilator, an alpha-blocking agent, and the mechanism of action was clearly corporal smooth muscle relaxation. This technique, which is also referred to as multiplereaction monitoring where to purchase clonazepam in canada (mrm), is used for quantitative analysis in chemicaland pharmaceutical development and in bioanalysis in combination withhigh-pressure liquid chromatography (fiplc).nuclear magnetic resonance spectrometry ( nmr )nmr is a radio-frequency spectroscopy method based on the magnetic fieldthat is generated by the spinning of electrically charged atomic nuclei (e.protons, 13 c, 19 f, 31 p). order sibutramine online in the uk most cases of argyria although drug development is a order sibutramine online in the uk structured process, it allows for the adaptation of the several steps to be taken due to the specific needs of the therapeuticarea, the nature of the drug and its route of administration.
This parameter is relatedclosely to the rate of absorption of the drug from a formulationand may be used as a simple measure of rate of absorption butis normally not evaluated statistically.to illustrate the importance of tmax, suppose that the twocurves in figure 5-6 now represent two formulations of an an-algesic and that in this case the mec is 2.0g/ml. This method as-sumes a linear order sibutramine online in the uk function, and its accuracy increasesas the number of appropriate sampling intervals are increased.table 5-1 and figure 5-7 describe the process for calculating theauc using the trapezoidal rule.returning to figure 5-6, the curves, although much differentin shape, have approximately the same areas (a = 34.4 μg/ml× h; b = 34.2 μg/ml × h), and both formulations can be consid-ered to deliver the same amount of drug to the systemic circula-tion. (60 grs.sodii citrotartras effervescens (b.) 60-120 grs.these two powders contain bicarbonate of sodium and citric and tartaricacids and order sibutramine online in the uk effervesce when put in water.acetate and citrate of potassium have been largely used as diuretics and inthe treatment of gout and rheumatism. The respiration should be stimulated byrespiratory stimulants, and, if necessary, artificial respirationshould be performed. The effects of group systematic desensitization on secondary erectile failure. order sibutramine online in the uk thesesymptoms from the alimentary tract are accompanied by giddiness,cramps in the muscles, headache, and soon by collapse, with colddamp skin, pallor, feeble pulse and weak, sighing respiration; thislater passes into coma, and death follows with or without convulsions.in cases in buy cheap tramadol in thailand which the dose is smaller than the fatal one, or in which muchof the poison is eliminated by vomiting, the patient may recover with-out further symptoms than those already described. This higher temperature is maintained by anincreased metabolism or heat formation, and also order sibutramine online in the uk in most cases by alessened dissipation. Treatment targetsthese aspects, often by blocking one or other of the counterregulatory mechanisms.cardiac preload, the cardiac filling pressure, is determined byblood volume – increased by salt and water retention – andcapacitance vessel tone, increased by sympathetic nervoussystem activation. One world flealth (www.oneworldhealth.org)and the global alliance for tuberculosis (tb) drug development (www.tballiance.org).new drugs are developed by drug development teams supported by functional departments such as order sibutramine online in the uk clinical operations, pharmaceutical developmentor toxicology. Mean terminal half-life in cheap meridia order online plasma was 4.5 hours(range, 3.3-13.4 hours; n=12). This isindeed the case of the furanocoumarins in grapefruit juice purchase valium oakland thatinactivate cyp3a4 in the intestinal mucosa and consequentlyenhance its where to purchase ambien 10mg online with paypal proteolytic degradation. A request to extend approval is currently under review at omb. The increased salivation,lachryroation and sweating are followed by a diminution of thesesecretions; the spasmodic contraction of the smooth muscles ofthe intestines is followed by relaxation. This reduced exposure can be anticipated to decrease the efficacy of tadalafil;the magnitude of decreased efficacy is unknown. The value of cheapest generic valium in thailand the action onthe heart is much decreased by the great irregularity of rhythm,which caffeine often produces. Some medicines used to treat other illnesses may decrease order sibutramine online in the uk your desire for sex, or make it order sibutramine online in the uk difficult to have an erection. (sildenafil) - pills made by order sibutramine online in the uk phizer, is an oral medication for erectile dysfunction (ed). One main cause of ed is restriction order sibutramine online in the uk of blood flow to the penis, which can be caused by atherosclerosis, or buildup of plaque in the arteries. On account of both its depressing eflfect on thesecretion of hydrochloric add and its paralyzing effect upon thepyloric sphincter, atropine has been used with much success, bothinternally and by subcutaneous injection, in diseases of the stomach attended with order sibutramine online in the uk hyperacidity and pylorospasm, as ulcers anderosions.atropine finds a great field of usefulness in ophthalmology,where it is employed to dilate the pupil and to paralyze accommodation in order to permit of examination of the eye. Further evidenceof the action of cocaine on the cerebrum is offered by its effects onmuscular work. It is of the consistency of pills and is alwaysprescribed in this form. But the fibrin-ferment is not formed except in the presence of calcium salts, andwhen oxalates are added to the blood before this ferment is developed,they prevent its formation and hinder clotting. The fate of the other antipyreticsresembles that xanax 1mg prescription online legal of antifebrine, the quinoline derivatives undergoing a partialoxidation resulting in a body analogous to paramidophenol, while the phene-tidine compounds are buy tramadol online without a prescription partially decomposed and order sibutramine online in the uk appear in the urine as glycu-ronates of order sibutramine online in the uk phenetidine. With modern methods cocaine is much lessdangerous and it has proved more reliable in practice than any of itsrivals. The absorption is very rapid, mercuryappearing in where to buy zolpiem in mexico the urine in the course of an hour, but the maximumis soon reached and much of the metal is eliminated in two or threedays. 8 mg/kg iv) may beuseful during regional anesthesia when additional analgesia isneeded (eg, cesarean delivery under neuraxial anesthesia with aninsufficient regional block). Forexample, sops describe the order sibutramine online in the uk quality management system (qms) of the drugdevelopment organisation, drafting and reviewing of essential study docu-ments, selection of participating countries and centres in clinical trials, generalprinciples of monitoring clinical trials, pharmacovigilance in clinical trials, ini-tial and continuous training of staff members, etc. Or are often the first treatment tried for erectile adipex and prozac dysfunction. Prevention of explicit memory (awareness) hasspurred the development of monitors such as the bispectralindex, electroencephalogram, cheap clonazepam 2mg online with american express and entropy monitor of auditoryevoked potentials to recognize inadequate planes of anesthesia.consciousnessthe ability of anesthetic drugs to abolish consciousness requiresaction at anatomic order sibutramine online in the uk locations responsible for the order sibutramine online in the uk formation ofhuman consciousness. Two otherstudies showed that finasteride at 5 times the dosage of propecia (5 mg daily) produced significantmedian decreases of approximately 0.5 ml (-25%) compared to placebo in ejaculate volume, but this wasreversible after discontinuation of treatment.in the clinical studies with propecia, the incidences for breast order sibutramine online in the uk tenderness and enlargement,hypersensitivity reactions, and testicular pain in finasteride-treated patients were not different from thosein patients treated with placebo.postmarketing experience for propecia (finasteride 1 mg)breast tenderness and enlargement; depression; hypersensitivity reactions including rash, pruritus,urticaria, and swelling of the lips and face; testicular pain; and male breast cancer. (after bradbury.)nitrite of amyl given by the stomach is very much less active thanwhen inhaled, as the nitrous acid is freed by the gastric juice andimmediately decomposed. Avoid fluoroquinolones, including cipro xr, in patients who have a history of tendon disorders or have experienced tendinitis or tendon rupture serious and fatal reactions have been reported in patients receiving buy meridia legally online concurrent administration of cipro xr and theophylline. The toxic symptoms are vomiting,pain in the abdomen, muscular tremor, convulsions of an epilepgroup of order sibutramine online in the uk camphor. Qa establishes systems for ensuringthe quality of the product. Hepatotoxicity (halothane hepatitis) hepatic dysfunc-tion following surgery and general anesthesia is most likely causedby hypovolemic shock, infection conferred by blood transfusion,or other surgical stresses rather than by volatile anesthetic toxicity.however, a small subset of individuals previously exposed tohalothane has developed fulminant order sibutramine online in the uk hepatic failure. Later, the entirecentral nervous system is paralyzed producing unconsciousness,collapse and death due mainly to paralysis of the respiratorycentre in the meduua. Most prod-ucts require at least 24 months shelf life to be commerciallyviable. P, a fibre of the nmlargcul passing from thebrain to the ciliary ganglion n, in which it terminates around a nerve cell, which sendsan axis cylinder to terminate, m , order sibutramine online in the uk in the circular fibres of the iris.
Change in erection quality with erectile function, hardness, and psychosocial measures in men treated with sildenafil for erectile dysfunction. This explains the relief of afterdinner fullnessby a small glass of brandy.alcohol has a very marked action on the metabolism depending on several factors, one of these being the fact that it is oxidized in the living organism to carbon dioxide and water. Large quantities of quinine throw the muscle into rigor, which re-sembles that produced order sibutramine online in the uk by caffeine, order sibutramine online in the uk and is probably associated with its actionin accelerating the coagulation of myosin (furth).the nerve trunks are said to be remarkably tolerant to solutions of quinine,which do not lessen their irritability when applied locally in sufficient quantityto cause marked abnormalities in the muscular contraction. Pyloriresistance to cip (5.5%). (yiiz)' average (u.fluideztractum buchu (u.uva ursi (u.), leaves of arctostaphylos uva ursi or bearberry.fluidextractum uva ursi (u. For example, manyof the vitamins are little affected by irradiation in the solidstate but are decomposed appreciably in solution. The mechanismsunderlying halothane hepatotoxicity remain unclear, but studiesin animals implicate the formation of reactive metabolites thateither cause direct hepatocellular damage (eg, free order sibutramine online in the uk radicals) orinitiate immune-mediated responses. Forexample, sops describe the quality management system (qms) of the drugdevelopment organisation, drafting and reviewing of essential study docu-ments, selection of order sibutramine online in the uk participating countries and centres in clinical trials, generalprinciples of monitoring clinical trials, pharmacovigilance in clinical trials, ini-tial and continuous training of staff members, etc. The increased rhythm of the heart leads to aslight rise in the blood-pressure, which sinks again as the pulse becomesslower. I wanted to embrace my love for homeopathy and natural remedies. order sibutramine online in the uk it is often administered with cocaine in opera-tions on the eye (1 of adrenaline solution in 10). In the frog it induces weakness of themuscles and paralysis.although ammonium is not a metal, its behavior in the body resem-bles in many points that of the fixed alkalies, and it may therefore1 the still rarer metals yttrium, erbium, beryllium, didymium and lanthanum havescarcely received examination except at order sibutramine online in the uk the hands of brunton and cash, and are not ofsufficient importance to require further mention here.516 substances acting after absorptionbest be studied along with them. Consistency alsocan be measured by the helipath attachment to a high-viscosityviscometer or by a burrell severs rheometer. This body has also been called epinephrine, siiprarenin,adrin, adnephrin, suprarenalin, etc., and has been prepared by various firmsin standard where to buy lorazepam online legit solutions.group of lodothyrin.the thyroid gland of animals and its active principlelodothyrin produce marked changes in the order sibutramine online in the uk metabolism.these consist of a great diminution of weight due to an increase inthe burning up of the body tissues; at first, of the fats alone, later, alsoof the proteids. Benzodiazepines list it forms crystalhzable salts with an intenselybitter taste. Thered amorphous phosphorus is much less poisonous than the ordinaryyellow form, because it is less soluble and also less volatile, and conse-quently fails to be absorbed.phosphorus exists in the blood as such, and the effects on the tissuesare unquestionably due to the element itself, and not to the oxygenor hydrogen compounds, as has been supposed. All of these organic compounds are much less poisonousto man order sibutramine online in the uk and the higher animals than inorganic arsenic, while order sibutramine online in the uk theymaintain the poisonous buy cheap alprazolam 1mg in australia action toward the protozoa that infect order sibutramine online in the uk theblood and tissues. Either the clinical developmentplan explores these cheapest generic xanax 2mg online legitimate differences from the start with specific studies in early drugdevelopment, followed by multi-regional clinical trials in late development, oralternatively, the clinical development is conducted entirely in one region orpopulation, and is later supplemented with a bridging study in (each of) thenew region(s) or population(s) in order to verify whether the initial resultscan be used to substantiate order sibutramine online in the uk worldwide drug approval.there are numerous operational and logistic challenges to conduct a globaldrug development programme, especially with regard to large multi-regionalclinical trials, such as:- sufficient knowledge of region- or country-specific regulatory require-ments;- identification and choice of participating countries and investigator sites;- production of study drugs and management of the drug-supply chain(including customs clearance); - document handling in different languages; and- monitoring or auditing of sites all over the world.therefore, most (even large multinational) pharmaceutical companies tend tooutsource all or part of these activities to large full-service contract researchorganisations (cros) that operate worldwide, but without order sibutramine online in the uk delegating eithertheir responsibility or their accountability.finally, the globalisation of drug development has had a profound impacton the geographical distribution of locations where clinical trials are per-formed. The time of dosing (morning versus evening) had no clinically relevant effectson the rate and extent ofabsorption.renal insufficiencyin clinical pharmacology studies using single-dose tadalafil (5to 20 mg), tadalafil exposure (auc)approximately doubled in subjects with mild (creatinine clearance 51 to 80 ml/min) or moderate(creatinine clearance 31 to 50ml/min) renal impairment and in subjects with end-stage renal diseaseon dialysis.haemodialysis contributes negligibly to tadalafil elimination.27hepatic insufficiencytadalafil exposure (auc) in subjects with mild and alprazolam 1mg fast shipping moderate hepatic impairment (child-pugh classa and b) is comparable to exposure order sibutramine online in the uk in healthy subjects when a dose of 10 mg is administered. order sibutramine online in the uk 28 the time is in hours to show the gradualrecovery. It forms stable salts with adds.pilocafpinfle hydrochloridum (u.), white crystals, soluble in waterand alcohol. Tularensis live vaccine strain,showed that a single dose of liposomal ciprofloxacin given by the intranasal orinhalational route could provide protection in a mouse model of pneumonic tularemia.liposomal ciprofloxacin offered better protection than ciprofloxacin given by the sameroutes. For patients with moderate hepatic impairment (child-pugh b), a starting dose of 5 mg is recommended. The determination of a recommendedsafe starting dose for a fih clinical trial is discussed in detail in chapter 5. Pde5 than for pde3, an enzyme found in the heart and blood vessels. Instead of the fruitjuices, carbonic acid waters may be advised, and occasionally other acids, suchas phosphoric or sulphuric, are prescribed to give flavor.acids are also used in certain forms of dyspepsia in w r hich thehydrochloric acid of the stomach is deficient. Despite increasinguse of various kinds of alerting cheapest generic diazepam 5mg with visa services and facilities, many ofthem computer-based, for retrieval or retrospective search ofpertinent information, lorazepam 1mg drugs online personal perusal of literature remainscritical, and the ability to initiate desktop searches is funda-mental to independent scientific research. Stability study requirements and expiration dating are coveredin the current good manufacturing practices (cgmps),5theusp,6and the fda and ich guidelines.good manufacturing practicesthe gmps5as stated in us requires thatthere shall be a written testing program designed to assess thestability characteristics of drug products. It consists of metallic iron, with a small amountof the magnetic oxide.) ; b.ferri carbonas saccharatus (u.), saccharated where to purchase tramadol with american express ferrous carbonate, is formed by precipitating ferrous sulphate with sodium bicarbonate,washing the precipitate and order sibutramine online in the uk adding sugar. The symptoms in mammals are increasinglassitude and weakness, with augmented reflex excitability, order sibutramine online in the uk tremors, and finallyconvulsions. Potency drugs a and b are said to be more potent thandrugs c and d because of the relative positions of their dose-re-sponse curves along the dose axis of figure 2-15. It is the purchase sibutramine 10mg with american express most popular because it is used for the blue times. It may be remarked in passing thatseveral other poisons, such as bismuth, and aloin, occasionally inducethis deposit of lime in the kidneys.this renal necrosis occurs chiefly in corrosive sublimate poisoning,mercury 629as the more slowly absorbed, insoluble order sibutramine online in the uk preparations apparently do notoften accumulate in sufficient quantity in the blood to order sibutramine online in the uk induce suchsevere effects. An alprazolam cheapest overview of the drug life cycle.there are two kinds of risk in drug rd: a pilot trial for male erectile dysfunction at three separate clinics. 45piscidia erythrena was at one time much in order sibutramine online in the uk vogue in theunited states as a sleep producer and to check cough, but it wasrecently discovered that its active principle had no narcotic effectand in large doses acted much like physostigmine.summary of the "group action —depression of thesense of pain before complete narcotic auction occurs. However, salting out isreversible order sibutramine online in the uk and subsequent addition of water redissolves the precipitated polymers buy tramadol 200mg online with american express and liquefies their gels. The clinicalimpact of these qt changes is unknown (seeprecautions,congenital or acquired qt prolongation).effects on exercise treadmill test in patients with coronary artery disease (cad):in twoindependent trials that assessed 10 mg (n=41) and 20 mg (n=39) vardenafil, respectively,vardenafil did not alter the total treadmill exercise time compared to placebo. Enzymes that are capable of dissolving a recently formedblood clot, such as streptokinase, tissue plasminogen activator(tpa), and urokinase, have order sibutramine online in the uk been approved and are useful underspecific primary care circumstances in the treatment of stroke.major advances have been made in the field of gastrointestinalphysiology; many new gastrointestinal polypeptide hormoneshave xanax 2mg prescription regulations been isolated and characterized, and their primary func-tions have been determined. Indeed, clinical disturbances in sexual interest and activity often reported by depressed persons are associated with objective changes in sexual neurophysiology (thase, et al, 1987). order sibutramine online in the uk emotional and functional order sibutramine online in the uk coping outcomes of men receiving pharmacologic erection therapy for impotence. Saline diuretics are the chlorides of sodium, potassiumand ammonium, though these are seldom prescribed for this purpose;their diuretic action is seen, however, in the treatment at spas andwatering-places. Thus, liquidcrystalline phases and gel structures can form from the combination of the basic three-component mixture of water, oil, andsurfactant (emulsifying order sibutramine online in the uk agent).